Intelligent micelles for on-demand drug delivery targeting extracellular matrix ...

Time：2024/10/20 15:29:20

Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly tumors, in which the key pathological features of dense extracellular matrix (ECM) limit the penetration of chemotherapy drugs and participate in the formation of tumor immunosuppressive microe...

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A Peptide-Drug Conjugate-Based Nanoplatform for Immunometabolic Activation and I...

Time：2024/9/30 13:14:09

Alzheimer's disease (AD) is a progressive neurodegenerative disease. However, there is currently a lack of effective treatments to inhibit its progression, making it one of the most challenging brain diseases to treat clinically. Recent studies have shown tha...

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Recent advances in biomimetic strategies for the immunotherapy of glioblastoma.

Time：2024/8/23 19:29:12

Immunotherapy is regarded as one of the most promising approaches for treating tumors, with a multitude of immunotherapeutic thoughts currently under consideration for the lethal glioblastoma (GBM). However, issues with immunotherapeutic agents, such as limit...

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Reconciling the Cooperative-Competitive Patterns Among Tumor and Immune Cells fo...

Time：2024/4/23 14:58:14

The intricate interplay between tumor cells, neighboring immune cells, and various immune cell types involves complex competitive-cooperative patterns rewired through metabolic and immune signals, which are essential for shaping the immunosuppressive tumor mi...

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Therapeutic Regulation of Epigenetics in Cancer Treatment through Drug Delivery ...

Time：2024/4/6 19:01:02

In addition to genetic factors, epigenetic factors are also strongly associated with cancer, especially its malignant evolution. Although epigenetic-based cancer therapies have been used with some efficacy in hematologic malignancies, they remain ineffective ...

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