Targeting Multilayered Metabolic Networks in Brain Diseases: Emerging Perspectiv...

Time：2025/9/29 12:53:28

Brain metabolism is uniquely regulated, and alterations in its metabolic networks often serve as critical drivers of the onset and progression of brain diseases. Therapeutic strategies that target these metabolic changes are regarded as fundamental to disease...

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Mitocytosis-inducing nanoparticles alleviate gemcitabine resistance via dual dis...

Time：2025/8/19 17:20:48

Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumor types, and metabolic reprogramming is a central driver of its progression. By altering biosynthetic processes and energy metabolism pathways, metabolic reprogramming not only enhances ...

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Multiple-Stimuli-Responsive Biomimetic Polypyrrole Delivery System for Synergist...

Time：2025/6/24 13:35:48

Considering that currently used anti-epileptic drugs (AEDs) in clinical practice can only suppress abnormal discharges without intervening in inflammatory microenvironment, combining anti-inflammatory and antioxidant agents with AEDs isprobably an effective a...

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Disrupting Tumor Lactate Homeostasis to Sensitize Chemo-Immunotherapy Using a Gl...

Time：2025/6/9 10:45:01

Aberrantly elevated lactate flux in tumors is increasingly recognized as a key driver of metabolic symbiosis, immunosuppression, and ultimately, immunogenic chemotherapy resistance. Here, we propose a precise lactate homeostasis modulation strategy that selec...

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Manganese-based Virus-mimicking Nanomedicine with Triple Immunomodulatory Functi...

Time：2025/3/29 13:59:05

Brain metastasis is a significant contributor to mortality, impacting one in five cancer patients, with a median survival of merely 4 months. Patients with brain metastasis from triple-negative breast cancer (TNBC) often exhibit resistance to conventional the...

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