Disrupting Tumor Lactate Homeostasis to Sensitize Chemo-Immunotherapy Using a Gl...

Time：2025/6/9 10:45:01

Aberrantly elevated lactate flux in tumors is increasingly recognized as a key driver of metabolic symbiosis, immunosuppression, and ultimately, immunogenic chemotherapy resistance. Here, we propose a precise lactate homeostasis modulation strategy that selec...

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Manganese-based Virus-mimicking Nanomedicine with Triple Immunomodulatory Functi...

Time：2025/3/29 13:59:05

Brain metastasis is a significant contributor to mortality, impacting one in five cancer patients, with a median survival of merely 4 months. Patients with brain metastasis from triple-negative breast cancer (TNBC) often exhibit resistance to conventional the...

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Engineered Bacterial Outer Membrane Vesicles-Based Doxorubicin and CD47-siRNA Co...

Time：2025/3/5 14:19:00

Apart from the blood-brain barrier (BBB), the efficacy of immunotherapy for glioblastoma (GBM) is limited by the presence of intrinsic and adaptive immune resistance, implying that co-delivery of various immunotherapeutic agents or simultaneous regulation of ...

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A Methionine Allocation Nanoregulator for the Suppression of Cancer Stem Cells a...

Time：2025/2/24 10:40:43

Epigenetic dysregulation in tumors drives malignant progression, therapeutic resistance, and the formation of a pro-tumor immune microenvironment by altering gene expression and metabolic patterns. This uncontrolled metabolism fuels tumor proliferation and ep...

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Metabolic Nanoregulators Induce Ferroptosis and Change Metabolite Flow to Revers...

Time：2024/12/18 16:01:25

Malignant cells acquire metabolic adaptations that facilitate the utilization of energy and substances for supporting uncontrolled growth while also modulating the immune landscape of the tumor microenvironment (TME). Anti-tumor immune populations that exhibi...

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