Achievements：
Important progress on the basic research of novel drug delivery systems based on the nanotechnology has been achieved, including:
1. Employing endogenous transport mechanism to design targeted drug delivery systems: applying multiple receptors and transport pathways with tumor-targeted and high blood-brain-barrier crossing transport capacity, we evaluate their high efficiency mediated brain-targeted transport and the mechanism. Meanwhile we found that compared with antibody or protein with high molecular weight, small targeted molecules have higher fabricability and efficiency, which make them with better potential in drug development and clinical applications. Furthermore, based on the characteristic that blood-brain-barrier and glioma cells endow the same target, we select the choline&glucose derivate, which can target both blood-brain-barrier and glioma, to realize theencephalic drug dual-targeted focus, and to decrease the influence to the normal brain parts and peripheral tissues.
2. Design of microenvironmenttriggered targeted therapy strategy to realize targeted delivery and focused release: in line with the pathema’s physiology and pathologymicroenvironment characteristics,we construct the tissue/cell microenvironment triggered and controlled release system to modulate the drug focused release, which will provide theoretical references for the design of high efficiency and low toxic brain-targeted formulation.
3. In line with the pathema’s physiology and pathologycharacteristics, we design, synthesize and optimize polymer materials, which can “on-demand” fit the requirement for the drug or therapy ", to construct the carriers with highly drug-carrying, controlled release, biodegradable, low toxic and side-effect capacity. We mainly focused on the amino acid-based polymers.
4. Employing the nanotechnology based on the dendritic macromolecules and chitosan as carriers to increase the oral availability of insoluble drugs.
5. We have one PhD candidate winning the “Excellent Doctor Degree Dissertation of Shanghai City” and three mastercandidates wining “Excellent MasterDegree Dissertation of Shanghai City”.
