Shutting Down the ‘Language Encoder’: A Pathogen-Derived Nano-Interferer Disru...

Time：2025/12/3 13:25:00

Aberrant enhancement of terminal sialylation in glioblastoma (GBM) has been established as a critical metabolic determinant for maintaining membrane receptor homeostasis, constructing high-throughput intercellular communication networks, and ultimately promot...

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A Supramolecular Nanoscavengers: based "Cargo-Exchange" Breaking Cholesterol Met...

Time：2025/11/26 21:56:40

Glioblastoma is a common primary malignant brain tumor, the efficacy of these therapeutic modalities is constrained by several factors, including intricate signaling pathways, intratumoral genetic diversity, the blood-brain barrier (BBB), and an immunosuppres...

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Targeting Multilayered Metabolic Networks in Brain Diseases: Emerging Perspectiv...

Time：2025/9/29 12:53:28

Brain metabolism is uniquely regulated, and alterations in its metabolic networks often serve as critical drivers of the onset and progression of brain diseases. Therapeutic strategies that target these metabolic changes are regarded as fundamental to disease...

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Mitocytosis-inducing nanoparticles alleviate gemcitabine resistance via dual dis...

Time：2025/8/19 17:20:48

Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumor types, and metabolic reprogramming is a central driver of its progression. By altering biosynthetic processes and energy metabolism pathways, metabolic reprogramming not only enhances ...

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Multiple-Stimuli-Responsive Biomimetic Polypyrrole Delivery System for Synergist...

Time：2025/6/24 13:35:48

Considering that currently used anti-epileptic drugs (AEDs) in clinical practice can only suppress abnormal discharges without intervening in inflammatory microenvironment, combining anti-inflammatory and antioxidant agents with AEDs isprobably an effective a...

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