实验室副主任：占昌友
男，1984年生， 博士，复旦大学二级教授、博士生导师，国家杰出青年科学基金获得者、中组部青年千人、上海市重点创新团队负责人。率领团队长期从事脂质纳米药物基础与临床转化研究，聚焦脂质纳米药物体内过程与机体调控机制，研究成果为脂质纳米药物的设计开发和临床应用提供了重要依据。在相关领域权威期刊发表论文100余篇，回国后申请和授权中国发明专利及PCT专利10余项，多项实现了转化/转让。主持国家自然科学基金重点、杰青和上海市重大项目等，荣获2022年教育部青年科学奖、2019年中国药学会-以岭生物医药青年奖、2016年教育部自然科学奖二等奖和2016年上海市自然科学奖二等奖等。
代表性成果（10项以内）：
1. Tang W#, Zhang Z#, Li C#, Chu Y, Qian J, Ying T*, Lu W*, Zhan C*. Facile Separation of PEGylated Liposomes Enabled by Anti-PEG scFv. Nano Lett 2021, 21(23):10107-10113.
2. Jiang Z, Liu J, Guan J, Wang H, Ding T, Qian J*, Zhan C*. Self-adjuvant Effect by Manipulating Bio-nano Interface of Liposome-based Nanovaccines. Nano Lett 2021, 21(11):4744-52.
3. Guan J#, Wu E#, Jin P, Hou S, Qian J, Lu W, Yu B, Zhan C*. Interrogating preclinical study of liposomes: The effect of mouse strain reexamined. J Control Release 2021, 334:178-187.
4. Guan J#, Chen W#, Yang M, Wu E, Qian J, Zhan C*. Regulation of in vivo delivery of nanomedicines by herbal medicines. Adv Drug Deliv Rev 2021, 174: 210-228.
5. Chu Y#, Tang W#, Zhang Z*, Li C, Qian J, Wei X, Ying T, Lu W, Zhan C*. Deciphering protein corona by scFv-based affinity chromatography. Nano Lett 2021, 21 (5): 2124-2131.
6. Zhang Z#, Chu Y#, Li C#, Tang W, Qian J, Wei X, Lu W, Ying T*, Zhan C*. Anti-PEG scFv corona ameliorates accelerated blood clearance phenomenon of PEGylated nanomedicines. J Control Release 2021, 330: 493-501.
7. Wang H#, Ding T#, Guan J, Liu X, Wang J, Jin PP, Hou S, Lu W, Qian J, Wang W, Zhan C*. Interrogation of Folic Acid-Functionalized Nanomedicines: The Regulatory Roles of Plasma Proteins Reexamined. ACS Nano 2020, 14(11):14779-14789.
8. Ding T#, Guan J#, Long Q, Liu X, Qian J, Wei X, Lu W, Zhan C*. Natural IgM dominates in vivo performance of liposomes. J Control Release 2020, 319: 371-381.
9. Zhang Z, Guan J, Jiang Z, Yang Y, Liu J, Hua W, Mao Y, Li C, Lu W, Qian J, Zhan C*. Brain-targeted drug delivery by manipulating protein corona functions. Nature Commun 2019, 10(1):3561.
10. Guan J#, Shen Q#, Zhang Z, Jiang Z, Yang Y, Lou M, Qian J, Lu W, Zhan C*. Enhanced Immunocompatibility of Ligand-targeted Liposomes by Attenuating Natural IgM Absorption. Nature Commun 2018, 9(1)2982.
