实验室副主任：陆伟

      

     男，1978年出生，2000年毕业于复旦大学药学院，获理学学士学位；2005年获药剂学博士学位。同年留校担任讲师；2006年赴美国德克萨斯大学MD Anderson癌症中心从事分子影像学博士后研究，2009年升任讲师；2010年担任美国罗德岛大学药学院助理教授，2015年破格提前一年晋升为副教授，获终身教职；同年辞去美国教职，担任复旦大学药学院教授至今。国家海外高层次青年人才、东方学者特聘教授、上海市优秀青年学术带头人，上海市卫健委卫生健康学科带头人，全国优秀博士学位论文获得者。从事新型药物制剂与诊疗一体化药物研究。主持国家自然科学基金重大项目课题、重大研究计划培育项目、面上项目、美国NIH R01研究项目等。在Nat. Commun.，Adv. Funct. Mater.，ACS Nano等国际专业期刊发表学术论文70余篇。授权发明专利11项。获教育部自然科学奖一等奖（第4完成人）、上海市自然科学奖二等奖（第4完成人）。

 

代表性成果（10项以内）：

1、Wu A, Yang A, Tong Q, Wei G, Zhang S, Yu S, Zhang C, Xu J, Lu W*. A rationally designed cancer vaccine based on NIR-II fluorescence image-guided light-triggered remote control of antigen cross-presentation and autophagy. Acta Pharmaceutica Sinica B 2023;13(7):3121-3136.

2、 Lin H#, Tong Q#, Xu J, Li T, Yang A, Sun J, Lu W*.An “IgG-hitchhiking” approach for rapid tumor accumulation and clearance of photosensitizers.Journal of Controlled Release 2023; 356: 242-255.

3、 Tong Q, Xu J, Wu A, Zhang C, Yang A, Zhang S, Lin H, Lu W*.Pheophorbide A-Mediated Photodynamic Therapy Potentiates Checkpoint Blockade Therapy of Tumor with Low PD-L1 Expression.Pharmaceutics 2022;14(11):2513.

4、 GaoS#, Yu S#, Zhang Y#, Wu A#, ZhangS, Wei G, Wang H*, Xiao Z*, Lu W*.Molecularengineering of near-infrared-II photosensitizers with steric-hindrance effectfor image-guided cancer photodynamic therapy. Advanced Functional Materials 2021;31:2008356.

5、XuJ, Zheng B, Zhang S, Liao X, Tong Q, Wei G, Yu S, Chen G, Wu A, Gao S, Qian Y,Xiao Z, Lu W.* Copper sulfide nanoparticle-redirected macrophagesfor adoptive transfer therapy of melanoma. Advanced Functional Materials 2021;31:2008022.

6、Xu J#, Yu S#, Wang X, QianY, Wu W, Zhang S, Zheng B, Wei G, Gao S, Cao Z, Fu W, Xiao Z*, Lu W*. High affinity of Chlorin e6 toimmunoglobulin G for intraoperative fluorescence image-guided cancerphotodynamic and checkpoint blockade therapy. ACS Nano 2019;13(9):10242-60.

7、Zheng B, Xu J, Chen G, Zhang S, Xiao Z*, Lu W*. Bacterium-mimicking vector withenhanced adjuvanticity for cancer immunotherapy and minimized toxicity. AdvancedFunctional Materials 2019;29(33):1901437.

8、 Gao S, Wei G, Zhang S, Zheng B, Xu J, Chen G, LiM, Song S, Fu W, Xiao Z*, Lu W*.Albumin tailoring fluorescence and photothermal conversion effect ofnear-infrared-II fluorophore with aggregation-induced emission characteristics. NatureCommunications 2019;10(1):2206.

9、Gu X, Qiu Y, Lin M, Cui K, Chen G, Chen Y, Fan C,Zhang Y, Xu L, Chen H, Wan JB, Lu W*,Xiao Z*. CuS nanoparticles as a photodynamic nanoswitch for abrogating bypasssignaling to overcome Gefitinib resistance. Nano Letters 2019;19(5):3344-52.

10、 Wang X, Guo L, Zhang S, Chen Y, Chen YT, Zheng B,Sun J, Qian Y, Chen Y, Yan B, Lu W*.Copper Sulfide Facilitates Hepatobiliary Clearance of Gold Nanoparticlesthrough the Copper-Transporting ATPase ATP7B. ACS Nano 2019;13(5):5720-30.