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Gradient Tumor Microenvironment-Promoted Penetrating Micelles for Hypoxia Relief and Immunosuppression Reversion in Pancreatic Cancer Treatment
Time：2023/6/14 23:35:59 Views：188
Recently, we developed a
hypoxia-responsive nanomicellar drug delivery system for pancreatic cancer
microenvironment, which can respond to the hypoxic microenvironment of
pancreatic tumors and enhance the penetration of the material into the internal
tumor while preserving the external matrix. The drug delivery system achieves
precise treatment of pancreatic cancer by maintaining the integrity of the
external matrix and limiting the metastasis of the internal tumor. At the same
time, micelles can reverse the degree of hypoxia in the microenvironment by
disrupting the redox balance in the tumor region, and improve the
chemotherapeutic effect against pancreatic cancer in multiple ways. This study
enriches the understanding and knowledge of the factors influencing pancreatic
cancer chemotherapy and provides new design concepts for future pancreatic
cancer treatment.
Related research (DOI: 10.1016/j.actbio.2023.05.047) has been
available online powered by Acta Biomaterialia (IF = 10.633).
Please kindly refer to https://authors.elsevier.com/c/1hCD36CFjZQDKC for more
information.
