ROS/Electro Dual-Reactive Nanogel for Targeting Epileptic Foci to Remodel Aberrant Circuits and Inflammatory Microenvironment
Time：2023/4/13 16:27:00 Views：190
We have recently reported
a hydrogel nanoparticle drug delivery system, or namely nanogel, which is
hopeful to address several problems facing the currently prevalent
anti-epileptic drug therapies in epileptic treatment.
A reactive oxygen
species-responding prodrug is designed based on a classic anti-epileptic drug
to combine anti-epileptic drugs with relieving oxidative stress, and then
covalently encapsulated in nanogel. The nanogel manages to cross the
blood-brain barrier by targeting L-type amino transporter 1, and then degrades
in epileptic foci under the stimulation of both reactive oxygen species and
electricity. Anti-epileptic drugs are therefore, released to suppress aberrant
firing and recover overexcited neurons. Meanwhile, prodrug in nanogel can also
scavenge reactive oxygen species to relief oxidative stress and chronic
inflammation, and stabilize glial cells. Through our treatment, not only the
neurons are protected against excitotoxicity, but also the neuroglia are
shielded from successive pathological activation. To conclude, this article
presents a nanogel drug delivery system that efficiently regulates the
epileptic microenvironment as a whole, and promises a more comprehensive
solution to epilepsy.
Related research
(DOI: 10.1021/acsnano.3c01140) has been available online powered by ACS
Nano (IF = 18.027). Please kindly refer to https://pubs.acs.org/doi/full/10.1021/acsnano.3c01140 for more information.
