A Triple Therapeutic Strategy with Antiexosomal Iron Efflux for Enhanced Ferroptosis Therapy and Immunotherapy
Recently, our group developed an
organic-inorganic hybrid nanodrug delivery system based on modulating the tumor
immune microenvironment, proposing a triple therapy with highly effective
anti-tumor effects. The article was published in the Small with the title
" A
Triple Therapeutic Strategy with Antiexosomal Iron Efflux for Enhanced
Ferroptosis Therapy and Immunotherapy ".
Ferroptosis, as a form of regulatory
cell death, has been shown to disrupt cellular redox homeostasis and induce
cell death, as well as enhance cellular immunogenicity. Direct delivery of iron-based
nanoparticles to increase intracellular iron content is one of the most direct
way to induce ferroptosis. In previous study, it was found that cells have an
iron homeostasis regulatory mechanism that efflux iron in the form of exosomes
in an environment with high iron concentration, producing a resistance to
ferroptosis.
In response to the above theoretical
basis, we developed a hybrid nanodrug delivery system that combines iron-based
nanoparticles adsorbed with siProminin2, making the nanoparticles release
oxaliplatin, iron, and siProminin2 in response to the microenvironment, which
serves to induce ferroptosis and immunogenic cell death. It has the effect of
inhibiting the crosstalk between the tumor microenvironment and inhibiting the
further metastasis of tumor.
Wang Yu, a doctoral student in our
research group, is the first author of the paper, and Professor Jiang Chen is
the corresponding author of the paper. We thank the National Natural Science
Foundation of China, Shanghai Academic Research Leader Program and other
projects for their support.
Link: https://onlinelibrary.wiley.com/doi/full/10.1002/smll.202201704
