Brain-Targeting Drug Delivery Systems
Based on the previous work of our group on brain-targeted delivery systems, we were invited to publish a review article on brain-targeted drug delivery systems. The article was published online in the international review journal WIREs Nanomedicine and Nanobiotechnology under the title of Brain-targeting drug delivery systems.
In recent years, the incidence and mortality of brain diseases have remained high, mainly due to two aspects: the conservation of the blood-brain barrier and the complexity of the brain microenvironment. However, through rationally designed targeted delivery systems, multiple physiological barriers can be overcome to precisely deliver therapeutic agents to the lesion site. Therefore, the design of targeted delivery systems for brain diseases has become a research hotspot in recent years.
This review systematically elaborates on the pathological features of major brain diseases (neurodegenerative diseases, stroke, brain tumors), changes in the blood-brain barrier, strategies for crossing the blood-brain barrier, and regulation strategies for the brain microenvironment. Finally, some existing problems in this field and new directions for future development are pointed out.
Peixin Liu, a 2019 direct doctoral student of the research group, is the first author of this paper, and Professor Chen Jiang is the corresponding author of the paper. Thanks for the support of the National Natural Science Foundation of China, the key projects of the Shanghai Science Foundation, and the major projects of Shanghai Science and Technology.
For more information: https://doi.org/10.1002/wnan.1818
